A cardiologist and Professor of Medicine at the University of Pennsylvania Perelman School of Medicine, Kiran Musunuru is a clinician and a researcher whose important work has moved the ball forward on gene therapy. As co-founder and scientific advisor to Verve Therapeutics, Kiran has a special perspective – an insider’s view of the business, from someone who is both an academic (MD, PhD, MPH) and a humanist at heart. No one better to discuss the news that broke last month, with early good reports on treatment for ATTR amyloidosis that uses lipid nanoparticles to deliver a CRISPR package for in vivo editing. Is this the breakthrough moment we’ve been waiting for since the Human Genome Project began? Yes, says Kiran Musunuru, going all-in on the next 5 years.